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Innovations in learning science is needed to answer the needs of the paradigm in 21^st century. Innovation in learning science can be achieved with STEM education because STEM education can accomodate STEM literacy learning and 21^st century skills learning. Teaching and Learning involves three important components, namely teachers, students, and teaching materials. Teaching materials is one of the important components in implementing teaching and learning because learning materials provides knowledge and skills that suits with the needs of students. The purpose of this research is to develop a STEM-based integrated science teaching materials themed blood. Teaching materials is developed by researchers through 4S TMD methods that consisting of selection, structurization, characterization, and dedactic reduction. This article describes the first step of development teaching materials, namely selection step. The selection step starts with the analysis of curriculum to find overlapping concept then created the integrated design model and alignment indicator achievement of learning. After that,  researcher develop the basic concepts related to the theme using international text books as resources. The last step, researcher develop values/skills that can be integrated, that is STEM education. The result of Selection step is knowledge related to the themed blood that is extent, depth, and appropriate; The concept is correct and build on the blood theme; and values/skills that integrated is STEM education. The evaluation of this stage is done by expert lecturers in the field of science education to assess the feasibility. After this stage is completed, it will be resumed to the structurization step.

STEM; teaching materials; integrated science