Learning physics based multirepresentation integrated guided inquiry is a learning physics with different ability of representations (graphs, data, formulas) through collect data, and finally the students find answers to questions (guided inquiry). The purpose of this research is to analyze the effectiveness of learning physiscs based multirepresentation integrated guided inquiry to improve students science literacy. This research was conducted on 15 students of class XII in Islamic Senior High School 2 Kediri city,in march academic year of 2017/2018. This research used pretest-posttest one group design to find out students science literacy. The research revealed that Learning physics based multirepresentation integrated guided inquiry is effective to improve students science literacy. It is indicated by the high result of the N-gain category. according to the results, it can be implied that learning physics based multirepresentation integrated guided inquiry is effective to improve students science literacy.