This study aims to identify the potential of Tomini Bay resources that can be utilized as a source of chemistry learning. This research uses primary data and secondary data. Data collection were conducted through the combination of field research and literature studies. All data were analyzed using qualitative descriptive to analyze the potential of coastal and sea resources of Tomini Bay, which closely related to senior high school chemistry learning. The results showed that the potential resources of Tomini Bay in general include water, fisheries and marine cultivation, coral reefs and sea biota, mangrove forests, coastal plants, plantations, conservation and recreation areas, and mining. This potential can be used as a source of learning chemistry in thirteen materials. There is the scientific method, the essence and role of chemistry in life; chemical bonding and molecular structure; electrolyte and nonelectrolyte solutions; reduction and oxidation reactions; reaction rates; chemical equilibrium; acids and bases; colligative properties of solutions; period 4 transition elements and their compounds; macromolecules (polymers, carbohydrates, and proteins); lipids; hydrocarbons and petroleum; and colloidal systems.