This study has purpose to figure out the effectiveness blended learning activity in creative media course through blended learning for education chemistry students year 2017. The effectiveness declared from learning outcome and students’ response. The study was held in odd semester 2019-2020 for 15 meetings. After the instrument of blended learning (Students worksheets, visual and video/audio media) showed validity then learning activity was conducted from August to December 2019. There were combination of online (using vilearn- E-learning of Universitas Negeri Surabaya) and offline in teaching-learning activity for 15 meetings. Discussion, Assignments and its submission activities was using vilearn for 4 meetings, and the rest of meetings was using offline.  As final project, students in team presented chemistry creative media in internal exhibition. The theme of exhibition is physical chemistry creative media. The media assessed by lecturers and students (another year) who attended the exhibition. The data of learning outcome were obtained from final project score and assignments. While the data of students’ response were gained after the exhibition was held. The result of this study showed 100% students could achieve mastery learning outcome and student responded this course in good criteria. It can be concluded that chemistry creative media course effective to be conducted by using blended learning activity.