Abstract. Maternal mortality ratio is defined as the number of maternal deaths in every one hundred thousands live births. One of Indonesia’s Millennium Development Goals (MGDs) target is to reduce maternal mortality ratio. West Java, Central Java, and East Java contribute 26 percent of maternal mortality ratio in Indonesia, which is big, because  Indonesia has 33 provinces. This paper aim to analyze significant factors that affects maternal mortality in West Java, Central Java, and East Java. Multiple Linear Regression is a method to analyze relationship between a scalar dependent variable and one or more explanatory variable, but multiple linear regression model does not involve the locations of the event. Spatial Modelling is an analytical process conducted in conjunction with the geographical information system or location to describe basic processes and spatial features of study area. The objective of spatial modelling is to investigate relations of spatial objects or phenomena that occur in the real world.  According to Cressie (1993), event in a region tend to be influenced by events around them. Therefore, it is suspected that the maternal mortality ratio in a region is influenced by the maternal mortality ratio in surrounding area. We use Spatial Autoregressive Model (SAM) and Spatial Error Model (SEM) to inspect the factors affecting maternal mortality ratio in West Java, Central Java, and East Java. The results show that number of health workers, number of residents that are given RASKIN (Beras Miskin), and number of illiterate residents are significant factors that affects maternal mortality ratio in West Java, Central Java, and East Java.