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Brine Shrimp Lethality Test is the most convenient system for monitoring biological activities of various plant species. This method is very useful for preliminary assessment of toxicity of the plant extracts, it`s also used as a preliminary test against anti cancer activity by looking at the death of larvae caused by active compounds contained in the extract. This study aims to determine the effects of the cytotoxicity of leaf and fruit methanol extract Ficus cacira L. using Brine Shrimp Lethality Test (BSLT) method. Ficus carica L. Leaves and fruit are extracted by maceration method using methanol solvent. However, some conditions have to be resolved, especially in standard experimental conditions such as temperature, medium pH, salinity, and aeration. Furthermore, toxicity test using shrimp larvae Artemia salina Leach. Ficus carica L. extracts using this test have been determined in the concentration range of 10, 100, 200, 500 and 1000 ppm of the examined Ficus carica L. extract. Toxic effects of leaf and fruit extract can be seen between the percentage of larval mortality and log concentration to obtain LC50. leaf and fruits extract are toxic with values ​​of each LC50 are 44.66 and 45.76. This is because of compounds such as flavonoids, Triterpenoids and Sterols, Alkaloids and Saponins contained in leaf extracts and fruits of Ficus carica L.

cytotoxicity; Brine Shrimp Lethality Test; Ficus carica L.