The purpose of this study was to determine the effect of infrasound exposure (8-12 Hz) on the immune system (Immunoglobulin M and immunoglobulin G) in mice. This research method uses infrasound waves (8-12 Hz) in the form of infrasound waves, murottal al-Quran, and recitation of the al-Qur’an verses. Testing the immune system using the hemagglutination method, mouse antibodies are induced with goat red blood cell antigens.  The result of the immunological activity is the highest blood serum dilution in male rats that still shows agglutination from goat red blood cells collected and converted using the formula [2log (titer) +1]. Furthermore, the data were statistically analyzed using the ANOVA test with a significance level of 5%. The results showed no effect of infrasound (8-12 Hz) wave exposure on immunoglobulin M (IgM) with a significance value of 0.098. But there is an effect on Immunoglobulin G (IgG) with a significance value of 0,000 after that, then followed by the Duncan test which shows the highest value (3.1800) in the treatment of reading the al-Qur’an. Infrasound waves (8-12 Hz) can increase immunoglobulin G (IgG).